Hexosamine Biosynthesis Impairs Insulin Action via a Cholesterolgenic Response
نویسندگان
چکیده
منابع مشابه
Hexosamine biosynthesis pathway ( HBP )
27 There is increasing evidence that endoplasmic reticulum (ER) stress contributes to the 28 development atherosclerosis in diabetes mellitus. The purpose of this study was to determine the effects 29 of increased hexosamine biosynthesis pathway (HBP) flux on ER stress levels and the complications of 30 ER stress associated with diabetes and atherosclerosis in hepatic cells. Glutamine:fructose-...
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In the current study, we investigated the role of tribbles homolog 3 (TRIB3) in glucose-induced insulin resistance and whether the induction of TRIB3 by glucose is dependent on the nutrient-sensing hexosamine biosynthetic pathway (HBP) known to mediate glucose toxicity in diabetes. In diabetic rats, TRIB3 expression in skeletal muscle was increased after 10 days of hyperglycemia, and glycemia a...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2013
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2012-1213